Pathogenesis of Atopic Dermatitis: Current Paradigm

Atopic dermatitis: pathogenesis.

Atopic Dermatitis (AD) is a complex inflammatory cutaneous disorder characterized by immune mediated inflammation and epidermal barrier dysfunction. Arising from a complex interplay between environmental and genetic factors, the definitive etiology of AD is perplexing and controversial. Advances in molecular medicine are radically transforming our understanding of AD pathogenesis. Increasing kn...

Current Views of Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory skin disease that is considered familial with allergic features. It often occurs in patients with other atopic disorders such as asthma and allergic Rhinitis. The terms "dermatitis" and "eczema" are frequently used interchangeably. When the term "eczema" is used alone, it usually refers to AD (atopic eczema). "Eczematous" also connotes some scaling, c...

Pathogenesis and management of atopic dermatitis.

Atopic dermatitis: epidemiology and pathogenesis update.

The prevalence of atopic dermatitis (AD) has increased markedly in the United States over the past 5 decades, with current reports varying from 10% to 20% prevalence in US children, and new diagnoses are estimated at almost 11% per year. Recent research in AD pathophysiology and pathogenesis has demonstrated that AD is associated with epidermal barrier dysfunction and that mutations in the fila...

Update on Epidemiology, Diagnosis, and Disease Course of Atopic Dermatitis Review of Critical Issues in the Pathogenesis of Atopic Dermatitis Assessing the New and Emerging Treatments for Atopic Dermatitis The Changing Paradigm of Atopic Dermatitis Therapy

Current status of atopic dermatitis in Japan

Atopic dermatitis (AD) is a common, chronic or chronically relapsing, severely pruritic, eczematous skin disease. AD is the second most frequently observed skin disease in dermatology clinics in Japan. Prevalence of childhood AD is 12-13% in mainland Japan; however, it is only half that (about 6%) in children from Ishigaki Island, Okinawa. Topical steroids and tacrolimus are the mainstay of tre...